{"id":6290,"date":"2024-01-23T12:09:59","date_gmt":"2024-01-23T12:09:59","guid":{"rendered":"https:\/\/olmix.com\/?p=6290"},"modified":"2024-10-30T19:05:57","modified_gmt":"2024-10-30T18:05:57","slug":"new-biomarkers-for-exposure-to-fumonisins-in-chickens","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/en\/new-biomarkers-for-exposure-to-fumonisins-in-chickens\/","title":{"rendered":"New biomarkers for exposure to fumonisins in chickens?"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”horizontal” column_element_direction_tablet=”horizontal” column_element_direction_phone=”horizontal” column_element_alignment=”center” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#269756″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_icon icon_family=”fontawesome” icon_style=”default” icon_color_type=”color_scheme” icon_color=”Extra-Color-1″ icon_padding=”0px” pointer_events=”all” icon_fontawesome=”fa fa-clock-o” icon_size=”15″ margin_right=”7px” margin_top=”1px”][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#269756″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”med”]Fumonisin (FUM) toxicity is associated with the blocking of ceramide synthases (CerS), which affects the equilibrium of sphingolipids like sphinganine (Sa) and sphingosine (So) within cells.<\/b> While Sa accumulates in cells, the level of So is compensated, consequently affecting the Sa:So ratio which is used as a biomarker for exposure to fumonisins in many animal species.<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]However, <\/span>compensatory mechanisms to maintain ceramide level in cells<\/b> make irrelevant the use of this biomarker in some studies (depending on the level and time of exposure). Indeed, in this study, <\/span>the Sa:So ratio was not significantly affected in the plasma of chickens exposed to fumonisins<\/b>.<\/span><\/p>\n

However, a complete <\/span>analysis of different classes of sphingolipids<\/b> revealed that the ratio of the phosphate forms of Sa and So (Sa1P:So1P) was significantly increased by feeding fumonisins. <\/span><\/p>\n

This result is consistent with previous results suggesting that Sa1P:So1P ratio is a better biomarker for fumonisins exposure in plasma than Sa:So ratio. Similar effects of fumonisins were observed according to the size of the carbon chain of the ceramides. <\/span><\/p>\n

A significant increase in the C22-C24:C16 ratio was observed in plasma. Although the mechanisms behind these effects are not yet understood, this result suggests that <\/span>C22-C24:C16 sphingolipids ratios, in conjunction with the Sa1P:So1P ratio, could be good candidates for revealing fumonisin exposure in chicken plasma at doses that had no effect on the Sa:So ratio<\/b>.<\/span>[\/vc_column_text][image_with_animation image_url=”6291″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_column_text]Figure: Discriminant analyses (PLS-DA) of sphingolipids in plasma of chickens fed a control diet free of mycotoxins and chickens fed a diet containing circa 15 mg FUM\/kg for 14 or 21 days.<\/span><\/em>[\/vc_column_text][vc_column_text]Reference: Lassallette E., Nyvall-Collen P., Guerre P., Targeted sphingolipidomics indicates increased C22-C24:16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens. Ecotoxicology and Environmental Safety 268 (2023) 115697. <\/span><\/i>https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115697<\/span><\/i><\/a>\u00a0<\/span><\/i>[\/vc_column_text][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”accent-color” custom_height=”20″][vc_column_text]Interested in the work done by this research team on fumonisin effects in chickens?<\/b> Check out their previous study on the accumulation of FUM on chicken liver and breast tissue<\/strong><\/a><\/span>, and how Olmix Algoclay technology can reduce it<\/b>.<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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