{"id":6445,"date":"2024-01-19T10:40:30","date_gmt":"2024-01-19T10:40:30","guid":{"rendered":"https:\/\/olmix.com\/?p=6445"},"modified":"2024-11-27T11:28:19","modified_gmt":"2024-11-27T10:28:19","slug":"toxicidad-de-nuevos-tricotecenos-de-tipo-a-nx-y-3anx","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/es\/toxicidad-de-nuevos-tricotecenos-de-tipo-a-nx-y-3anx\/","title":{"rendered":"Toxicidad de nuevos tricotecenos de tipo A: NX y 3ANX"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; top_padding=&#8221;2%&#8221; constrain_group_4=&#8221;yes&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; 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column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;2%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;2%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;padding-2-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;left&#8221; left_margin=&#8221;7px&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;advanced&#8221; border_left_desktop=&#8221;1&#8243; column_border_color=&#8221;#007797&#8243; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][vc_column_text el_class=&#8221;med&#8221;]<strong>La toxina NX y su forma acetilada 3ANX son dos nuevos tricotecenos de tipo A producidos por\u00a0<em>Fusarium graminearum<\/em>.<\/strong>\u00a0Tienen una estructura similar a la del deoxinivalenol (DON) y del 3-acetildeoxinivalenol (3-ADON), otros tricotecenos de tipo B. Tanto NX como DON han mostrado efectos citot\u00f3xicos, inhiben la s\u00edntesis proteica, favorecen el estr\u00e9s oxidativo y tienen efectos proinflamatorios.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; column_margin=&#8221;50px&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;2%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;2%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][image_with_animation image_url=&#8221;5909&#8243; image_size=&#8221;large&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; constrain_group_1=&#8221;yes&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221; margin_top=&#8221;20&#8243; margin_bottom=&#8221;20&#8243;][vc_column_text]<strong>En un estudio efectuado por Pierron et al. (2022) se analiz\u00f3 la toxicidad intestinal de estas dos micotoxinas recientemente descubiertas, compar\u00e1ndola con la de DON<\/strong>, en c\u00e9lulas intestinales Caco-2 y con explantes intestinales de cerdos. La viabilidad de las c\u00e9lulas intestinales expuestas a la toxina NX fue similar a la de c\u00e9lulas expuestas a DON; mientras el 3ANX parece menos citot\u00f3xico. El examen histol\u00f3gico muestra\u00a0<strong>un efecto delet\u00e9reo m\u00e1s importante en los explantes intestinales con NX comparado con DON<\/strong>; sin embargo, este efecto fue menos marcado con el 3ANX. Estos resultados se correlacionan con el efecto de estas tres micotoxinas en el perfil de expresi\u00f3n g\u00e9nica intestinal, el efecto delet\u00e9reo es m\u00e1s importante con el NX comparado con DON, y todav\u00eda m\u00e1s comparado con 3ANX. Estas tres micotoxinas impactaron las mismas v\u00edas de se\u00f1alizaci\u00f3n, especialmente la inflamatoria y asociada a una respuesta inmunitaria.<\/p>\n<p>Por otro lado,\u00a0<strong>el NX modul\u00f3 m\u00e1s genes que el DON y el 3ANX<\/strong>. La activaci\u00f3n de genes inflamatorios puede explicar la modificaci\u00f3n y la degradaci\u00f3n de los tejidos intestinales. Estos cambios morfol\u00f3gicos pueden impactar las funciones de barrera y de absorci\u00f3n intestinales.<\/p>\n<p>De modo general,<strong>\u00a0estos resultados muestran que el NX y el 3ANX tienen efectos similares al DON, pero con gradientes de toxicidad diferentes: NX &gt; DON &gt;&gt; 3ANX<\/strong>. A la luz de estos resultados, seria pertinente incluir el NX y el 3ANX en el an\u00e1lisis de los riesgos de contaminaci\u00f3n con tricotecenos en el alimento.<\/p>\n<p><em><strong>Referencia<\/strong>: Pierron\u00a0<\/em>et al.<em>, 2022. Intestinal toxicity of the new type A trichothecenes, NX and 3ANX. Chemosphere, 288, 132415.<\/em><a href=\"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132415\" target=\"_blank\" rel=\"noopener\"><em> https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132415<\/em><\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; top_padding=&#8221;2%&#8221; constrain_group_4=&#8221;yes&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; gradient_type=&#8221;default&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221;&#8230;<\/p>\n","protected":false},"author":16,"featured_media":13061,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39],"tags":[],"class_list":{"0":"post-6445","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-myco-news-4"},"_links":{"self":[{"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/posts\/6445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/comments?post=6445"}],"version-history":[{"count":1,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/posts\/6445\/revisions"}],"predecessor-version":[{"id":13592,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/posts\/6445\/revisions\/13592"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/media\/13061"}],"wp:attachment":[{"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/media?parent=6445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/categories?post=6445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mycokingdom.net\/es\/wp-json\/wp\/v2\/tags?post=6445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}