{"id":16864,"date":"2025-02-17T17:00:48","date_gmt":"2025-02-17T16:00:48","guid":{"rendered":"https:\/\/mycokingdom.net\/?p=16864"},"modified":"2025-02-17T17:00:48","modified_gmt":"2025-02-17T16:00:48","slug":"dose-de-desoxinivalenol-recomendada-pela-efsa-afeta-a-saude-dos-suinos","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/pt-pt\/dose-de-desoxinivalenol-recomendada-pela-efsa-afeta-a-saude-dos-suinos\/","title":{"rendered":"Dose de desoxinivalenol recomendada pela EFSA afeta a sa\u00fade dos su\u00ednos"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_cta btn_style=”underline” heading_tag=”p” button_color=”default” text_color=”#269756″ button_border_thickness=”0px” link_type=”regular” alignment=”left” alignment_tablet=”default” alignment_phone=”default” display=”inline” display_tablet=”inherit” display_phone=”inherit” icon_family=”none” link_text=”Voltar \u00e0s not\u00edcias” url=”\/mycotoxins-pt\/#news” text=”\u2190” font_size_desktop=”14px”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”horizontal” column_element_direction_tablet=”horizontal” column_element_direction_phone=”horizontal” column_element_alignment=”center” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#269756″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_icon icon_family=”fontawesome” icon_style=”default” icon_color_type=”color_scheme” icon_color=”Extra-Color-1″ icon_padding=”0px” pointer_events=”all” icon_fontawesome=”fa fa-clock-o” icon_size=”15″ margin_right=”7px” margin_top=”1px”][vc_column_text][rt_reading_time label=”Tempo de leitura :” postfix=”minutes” postfix_singular=”minute”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#269756″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text css=”” el_class=”med” text_direction=”default”]Neste Myco’News, destacamos descobertas recentes sobre o desoxinivalenol (DON), que representa uma amea\u00e7a significativa \u00e0 sa\u00fade das vacas leiteiras, \u00e0 fun\u00e7\u00e3o ruminal e \u00e0 produ\u00e7\u00e3o de leite. Aqui est\u00e3o as tr\u00eas principais percep\u00e7\u00f5es de pesquisas recentes realizadas in vivo na China:<\/strong>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”” text_direction=”default”]No ano passado (junho de 2024), publicamos uma Myco’News sobre o efeito da baixa dose de Deoxinivalenol (DON) na sa\u00fade das aves. No entanto, essa micotoxina comum, produzida por v\u00e1rias esp\u00e9cies de Fusarium, tamb\u00e9m pode afetar a sa\u00fade dos su\u00ednos no n\u00edvel (900 ppb) recomendado pela EFSA.<\/p>\n

Os autores desse trabalho de pesquisa realizado na Fran\u00e7a observaram les\u00f5es no intestino delgado dos animais expostos ao DON. As principais altera\u00e7\u00f5es histol\u00f3gicas observadas nos animais tratados com DON foram a atrofia e a fus\u00e3o das vilosidades, com achatamento dos enter\u00f3citos (Fig. 1). No n\u00edvel molecular, foi observada uma tend\u00eancia de diminui\u00e7\u00e3o da express\u00e3o de citocinas e genes implicados na resposta imune (IL-1\u03b2, IL-1\u03b1, IFN-\u03b3, TGF-\u03b21) em animais que receberam ra\u00e7\u00e3o contaminada com 0,9 ppm de DON em compara\u00e7\u00e3o com os animais de controle.[\/vc_column_text][image_with_animation image_url=”16865″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_column_text css=”” text_direction=”default”]Figura 1. Morfologia intestinal de su\u00ednos no grupo de controle (CTL) e nos grupos de 0,9 e 3 ppm de DON. Em roxo, os resultados do experimento 1 e em azul, o experimento 2.<\/em>[\/vc_column_text][vc_column_text css=”” text_direction=”default”]A exposi\u00e7\u00e3o ao DON tamb\u00e9m afetou o f\u00edgado dos su\u00ednos. A ingest\u00e3o de DON causou desorganiza\u00e7\u00e3o, vacuoliza\u00e7\u00e3o citoplasm\u00e1tica e megalocitose dos hepat\u00f3citos. Foi observada uma redu\u00e7\u00e3o significativa na express\u00e3o g\u00eanica do ABCA1, envolvido no transporte de colesterol, no grupo de 0,9 ppm de DON. Os outros genes envolvidos na resposta imune (IL-1\u03b1) e na saciedade (CCK) mostram uma tend\u00eancia de diminui\u00e7\u00e3o da express\u00e3o no grupo com baixo teor de DON. Em contraste, os genes envolvidos no estresse oxidativo (SOD1, SOD2) mostram uma tend\u00eancia de aumento da express\u00e3o.<\/p>\n

Em conclus\u00e3o, os resultados deste estudo indicam que o n\u00edvel regulat\u00f3rio da UE de 0,9 mg de DON\/kg de ra\u00e7\u00e3o induz les\u00f5es no intestino e no f\u00edgado e a modula\u00e7\u00e3o da resposta inflamat\u00f3ria. Isso sugere que o atual n\u00edvel recomendado deve ser reconsiderado para garantir a sa\u00fade e o bem-estar ideais dos su\u00ednos.[\/vc_column_text][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”accent-color” custom_height=”20″][vc_column_text css=”” text_direction=”default”]Refer\u00eancias: Pierron A., Balbo L.C., Soler, L., Pinton P., Puel S., Laffitte J., Albin M., Loureiro Bracarense AP., Rodriguez M e Oswald I. 2024. Deoxynivalenol Induces Local Inflammation and Lesions in Tissues at Doses Recommended by the EU (O desoxinivalenol induz inflama\u00e7\u00e3o local e les\u00f5es em tecidos em doses recomendadas pela UE). Revista Internacional de Ci\u00eancias Moleculares, 25, 9790. https:\/\/doi.org\/10.3390\/ijms25189790[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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