{"id":6369,"date":"2024-01-18T16:13:56","date_gmt":"2024-01-18T16:13:56","guid":{"rendered":"https:\/\/olmix.com\/?p=6369"},"modified":"2025-01-14T14:49:32","modified_gmt":"2025-01-14T13:49:32","slug":"novas-biomarcadores-exposicao-fumonisinas-em-frangos","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/pt-pt\/novas-biomarcadores-exposicao-fumonisinas-em-frangos\/","title":{"rendered":"Novas biomarcadores para exposi\u00e7\u00e3o a fumonisinas em frangos?"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_cta btn_style=”underline” heading_tag=”p” button_color=”default” text_color=”#269756″ button_border_thickness=”0px” link_type=”regular” alignment=”left” alignment_tablet=”default” alignment_phone=”default” display=”inline” display_tablet=”inherit” display_phone=”inherit” icon_family=”none” link_text=”Voltar \u00e0s not\u00edcias” url=”\/mycotoxins-pt\/#news” text=”\u2190” font_size_desktop=”14px”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”horizontal” column_element_direction_tablet=”horizontal” column_element_direction_phone=”horizontal” column_element_alignment=”center” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#269756″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_icon icon_family=”fontawesome” icon_style=”default” icon_color_type=”color_scheme” icon_color=”Extra-Color-1″ icon_padding=”0px” pointer_events=”all” icon_fontawesome=”fa fa-clock-o” icon_size=”15″ margin_right=”7px” margin_top=”1px”][vc_column_text][rt_reading_time label=”Tempo de leitura :” postfix=”minutes” postfix_singular=”minute”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#269756″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”med”]A toxicidade de fumonisinas (FUM) \u00e9 associada ao bloqueio das ceramidas sintases (CerS), que afeta o equil\u00edbrio de esfingolip\u00eddios como a esfinganina (Sa) e esfingosina (So) dentro das c\u00e9lulas.<\/b>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Enquanto Sa \u00e9 acumulada nas c\u00e9lulas, o n\u00edvel de So \u00e9 compensado, consequentemente afetando a raz\u00e3o Sa:So, que \u00e9 usada como um biomarcador para exposi\u00e7\u00e3o a fumonisinas em muitas esp\u00e9cies animais. Entretanto, <\/span>mecanismos compensat\u00f3rios para manter o n\u00edvel de ceramida nas c\u00e9lulas<\/b> tornam irrelevante o uso deste biomarcador em alguns estudos (a depender do n\u00edvel e tempo de exposi\u00e7\u00e3o). De fato, neste estudo, <\/span>a rela\u00e7\u00e3o Sa: So n\u00e3o foi significativamente afetada no plasma dos frangos expostos \u00e0s fumonisinas<\/b>. Por\u00e9m, <\/span>uma an\u00e1lise completa de diferentes classes de esfingolip\u00eddios<\/b> mostrou que a rela\u00e7\u00e3o das formas de fosfatos de Sa e So (Sa1P:So1P) foi aumentada significativamente atrav\u00e9s da alimenta\u00e7\u00e3o com fumonisinas. <\/span><\/p>\n

Este resultado \u00e9 consistente com resultados pr\u00e9vios, sugerindo que a raz\u00e3o Sa1P:So1P \u00e9 um biomarcador melhor para a exposi\u00e7\u00e3o de fimonisinas em plasma do que a raz\u00e3o Sa:So. Efeitos similares das fumonisinas foram observados de acordo com o tamanho das cadeias de carbono das ceramidas. <\/span><\/p>\n

Um aumento significativo na propor\u00e7\u00e3o C22-C24:C16 foi observada em plasma. Embora os mecanismos por tr\u00e1s destes efeitos ainda n\u00e3o sejam compreendidos, este resultado sugere <\/span>que as propor\u00e7\u00f5es de esfingolip\u00eddios C22-C24:16, em conjunto com a propor\u00e7\u00e3o de Sa1P: So1P, poderiam ser bons candidatos para revelar a exposi\u00e7\u00e3o \u00e0 fumonisinas no plasma de frango em doses que n\u00e3o tiveram efeito na propor\u00e7\u00e3o Sa:So<\/b>.<\/span>[\/vc_column_text][image_with_animation image_url=”16631″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_column_text]Figura: An\u00e1lise Discriminante (PLS-DA) de esfingolip\u00eddios no plasma de frangos alimentados com dieta controlada livre de micotoxinas e frangos alimentados com dieta contendo de 15mg FUM\/KG por 14 ou 21 dias. <\/span><\/i>[\/vc_column_text][vc_column_text]Refer\u00eancia: Lassallette E., Nyvall-Collen P., Guerre P., Targeted sphingolipidomics indicates increased C22-C24:16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens. Ecotoxicology and Environmental Safety 268 (2023) 115697. <\/span><\/i>https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115697<\/span><\/i><\/a>\u00a0<\/span><\/i>[\/vc_column_text][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”accent-color” custom_height=”20″][vc_column_text]Se interessou pelo trabalho feito por essa equipe de pesquisa sobre os efeitos da fumonisina em Frangos? <\/b>Confira o estudo anterior feito pela mesma equipe sobre a acumula\u00e7\u00e3o de FUM no f\u00edgado e tecido mam\u00e1rio dos frangos<\/strong><\/a><\/span>, e como a tecnologia Algoclay da Olmix pode reduzi-la<\/b>. <\/b>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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