{"id":6401,"date":"2023-10-01T09:52:29","date_gmt":"2023-10-01T09:52:29","guid":{"rendered":"https:\/\/olmix.com\/?p=6401"},"modified":"2025-01-14T14:50:47","modified_gmt":"2025-01-14T13:50:47","slug":"interacoes-entre-medicamentos-e-micotoxinas","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/pt-pt\/interacoes-entre-medicamentos-e-micotoxinas\/","title":{"rendered":"Intera\u00e7\u00f5es entre medicamentos e micotoxinas"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_cta btn_style=”underline” heading_tag=”p” button_color=”default” text_color=”#269756″ button_border_thickness=”0px” link_type=”regular” alignment=”left” alignment_tablet=”default” alignment_phone=”default” display=”inline” display_tablet=”inherit” display_phone=”inherit” icon_family=”none” link_text=”Voltar \u00e0s not\u00edcias” url=”\/mycotoxins-pt\/#news” text=”\u2190” font_size_desktop=”14px”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”horizontal” column_element_direction_tablet=”horizontal” column_element_direction_phone=”horizontal” column_element_alignment=”center” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#269756″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_icon icon_family=”fontawesome” icon_style=”default” icon_color_type=”color_scheme” icon_color=”Extra-Color-1″ icon_padding=”0px” pointer_events=”all” icon_fontawesome=”fa fa-clock-o” icon_size=”15″ margin_right=”7px” margin_top=”1px”][vc_column_text][rt_reading_time label=”Tempo de leitura :” postfix=”minutes” postfix_singular=”minute”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#269756″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”med”]As contamina\u00e7\u00f5es por micotoxinas em ra\u00e7\u00f5es e alimentos s\u00e3o uma amea\u00e7a amplamente conhecida. Elas n\u00e3o s\u00f3 podem ter repercuss\u00f5es diretas na sa\u00fade animal e humana, como tamb\u00e9m podem interagir com outras subst\u00e2ncias xenobi\u00f3ticas, como medicamentos. Em 2022, Lootens <\/span>et al.<\/span><\/i> fizeram uma revis\u00e3o para entender melhor esse mecanismo. As micotoxinas \u2013 como todo xenobi\u00f3tico \u2013 passam por absor\u00e7\u00e3o, distribui\u00e7\u00e3o, metabolismo e excre\u00e7\u00e3o (ADME). <\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Seu metabolismo \u00e9 garantido principalmente por enzimas hep\u00e1ticas do complexo CYP450, o que tamb\u00e9m pode ocorrer com aproximadamente 80% dos medicamentos.<\/b> Diferentes tipos de medicamentos e micotoxinas podem ser indutores e inibidores de CYP450. <\/span>Os indutores levam \u00e0 forma\u00e7\u00e3o de mais metab\u00f3litos, o que \u00e9 satisfat\u00f3rio no caso de desintoxica\u00e7\u00e3o, mas n\u00e3o em caso de bioativa\u00e7\u00e3o <\/b>(por exemplo, convers\u00e3o de AFB1 em AFBO, exercendo carcinogenicidade). Inibidores levam a uma menor forma\u00e7\u00e3o de metab\u00f3litos.<\/span>[\/vc_column_text][image_with_animation image_url=”16660″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_column_text]\u00c9 mais prov\u00e1vel que os medicamentos afetem a farmacocin\u00e9tica das micotoxinas do que as micotoxinas afetem a disposi\u00e7\u00e3o dos medicamentos<\/b>, considerando suas respectivas concentra\u00e7\u00f5es de exposi\u00e7\u00e3o. Outro tipo de intera\u00e7\u00e3o ocorre quando h\u00e1 uma semelhan\u00e7a estrutural entre a micotoxina e o medicamento.\u00a0 Por exemplo, na presen\u00e7a de uma micotoxinas com uma estrutura az\u00f3lica, um medicamento antif\u00fangico az\u00f3lico pode interagir com a micotoxina em vez de interagir com os fungos visados. Por \u00faltimo, <\/span>a ruptura da barreira intestinal causada por micotoxinas citot\u00f3xicas, como a toxina T-2, tamb\u00e9m afeta a farmacodin\u00e2mica de determinados medicamentos.<\/b><\/p>\n

Para avaliar o impacto das contamina\u00e7\u00f5es por micotoxinas nos medicamentos, Lootens <\/span>et al.<\/span><\/i> relatam que o uso de modelo farmacocin\u00e9tico de base fisiol\u00f3gica (PBPK) pode ser uma ferramenta <\/span>in vitro<\/span><\/i> eficiente.<\/span><\/p>\n

Refer\u00eancia: Lootens, O.; Vermeulen, A.; Croubels, S.; De Saeger, S.; Van Bocxlaer, J.; De Boevre, M. Possible Mechanisms of the Interplay between Drugs and Mycotoxins\u2014Is There a Possible Impact? Toxins 2022, 14, 873.\u00a0<\/span><\/i> https:\/\/doi.org\/10.3390\/toxins14120873<\/a><\/em>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default”…<\/p>\n","protected":false},"author":16,"featured_media":16655,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":{"0":"post-6401","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-myco-news-2"},"_links":{"self":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts\/6401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/comments?post=6401"}],"version-history":[{"count":2,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts\/6401\/revisions"}],"predecessor-version":[{"id":16665,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts\/6401\/revisions\/16665"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/media\/16655"}],"wp:attachment":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/media?parent=6401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/categories?post=6401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/tags?post=6401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}