{"id":6436,"date":"2023-01-12T10:33:41","date_gmt":"2023-01-12T10:33:41","guid":{"rendered":"https:\/\/olmix.com\/?p=6436"},"modified":"2025-01-14T15:01:58","modified_gmt":"2025-01-14T14:01:58","slug":"biomonitoramento-de-micotoxinas-em-suinos","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/pt-pt\/biomonitoramento-de-micotoxinas-em-suinos\/","title":{"rendered":"Biomonitoramento de micotoxinas em su\u00ednos"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_cta btn_style=”underline” heading_tag=”p” button_color=”default” text_color=”#269756″ button_border_thickness=”0px” link_type=”regular” alignment=”left” alignment_tablet=”default” alignment_phone=”default” display=”inline” display_tablet=”inherit” display_phone=”inherit” icon_family=”none” link_text=”Voltar \u00e0s not\u00edcias” url=”\/mycotoxins-pt\/#news” text=”\u2190” font_size_desktop=”14px”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”horizontal” column_element_direction_tablet=”horizontal” column_element_direction_phone=”horizontal” column_element_alignment=”center” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#007797″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_icon icon_family=”fontawesome” icon_style=”default” icon_color_type=”color_scheme” icon_color=”Extra-Color-2″ icon_padding=”0px” pointer_events=”all” icon_fontawesome=”fa fa-clock-o” icon_size=”15″ margin_right=”7px” margin_top=”1px”][vc_column_text][rt_reading_time label=”Tempo de leitura :” postfix=”minutes” postfix_singular=”minute”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#007797″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”med”]Avaliar a exposi\u00e7\u00e3o dos animais a micotoxinas \u00e9 importante para gerenciar o risco de micotoxinas<\/strong>, uma abordagem cl\u00e1ssica para avaliar a exposi\u00e7\u00e3o dos animais consiste em verificar a contamina\u00e7\u00e3o nos alimentos dos animais.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”middle” column_margin=”50px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]No entanto,\u00a0o monitoramento de micotoxinas em ra\u00e7\u00f5es tem algumas limita\u00e7\u00f5es<\/strong>, relacionadas \u00e0 distribui\u00e7\u00e3o desigual de micotoxinas nas mesmas ou porque n\u00e3o reflete a exposi\u00e7\u00e3o individual. Diante disso,\u00a0o estudo da presen\u00e7a de micotoxinas em matrizes biol\u00f3gicas (urina, fezes, sangue), tamb\u00e9m chamado de biomonitoramento, pode ser uma op\u00e7\u00e3o<\/strong>. Quando se trata de su\u00ednos,\u00a0o desoxinivalenol (DON) e a zearalenona (ZEN)<\/strong>\u00a0s\u00e3o os mais estudados.<\/p>\n

Estudos sobre o ZEN<\/strong>\u00a0indicam que os n\u00edveis urin\u00e1rios de ZEN e seu metab\u00f3lito de fase I \u03b1-zearalenol t\u00eam uma boa correla\u00e7\u00e3o com os n\u00edveis de ra\u00e7\u00e3o de ZEN, tornando-os biomarcadores adequados de exposi\u00e7\u00e3o ao ZEN em su\u00ednos.<\/p>\n

Estudos de DON<\/strong>\u00a0mostram uma boa correla\u00e7\u00e3o entre os n\u00edveis de alimenta\u00e7\u00e3o de DON e os n\u00edveis urin\u00e1rios e s\u00e9ricos de DON e DOM-1. Assim, sua an\u00e1lise na urina e no soro s\u00e3o biomarcadores adequados de exposi\u00e7\u00e3o a DON em su\u00ednos.[\/vc_column_text][image_with_animation image_url=”16700″ image_size=”large” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” constrain_group_1=”yes” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default” margin_top=”20″ margin_bottom=”20″][vc_column_text]Glucuronides conjugate of both ZEN and DON could also be candidate markers, but their quantification has more analytical constraints. No relevant biomarker of ZEN and DON exposure was identified in the feces of pigs.<\/p>\n

When it comes to multi-mycotoxins biomonitoring, urine seems to be the most suitable matrix to obtain a good dose-response correlation, especially for DON and ZEN.\u00a0<\/strong>This model could be used for mycotoxin detoxifying agents\u2019 efficacy evaluation in pigs. The choice of suitable biomarker, matrix, and sampling time plays the most important role in adequate exposure assessment, and the interpretation of the results cannot be done without the corresponding feed analysis.\u00a0All this considered, biomarkers as a diagnostic tool are only possible within scientific trials.<\/strong><\/p>\n

 <\/p>\n

O conjugado de glucuronidos de ZEN e DON tamb\u00e9m pode ser um marcador candidato, mas sua quantifica\u00e7\u00e3o tem mais restri\u00e7\u00f5es anal\u00edticas. Nenhum biomarcador relevante da exposi\u00e7\u00e3o a ZEN e DON foi identificado nas fezes de su\u00ednos.<\/p>\n

Quando se trata de biomonitoramento de multimicotoxinas, a urina parece ser a matriz mais adequada para obter uma boa correla\u00e7\u00e3o dose-resposta, especialmente para DON e ZEN<\/strong>. Este modelo poderia ser usado para a avalia\u00e7\u00e3o da efic\u00e1cia de agentes desintoxicantes de micotoxinas em su\u00ednos. A escolha do biomarcador, da matriz e do tempo de amostragem adequados desempenha o papel mais importante na avalia\u00e7\u00e3o adequada da exposi\u00e7\u00e3o, e a interpreta\u00e7\u00e3o dos resultados n\u00e3o pode ser feita sem a an\u00e1lise correspondente dos alimentos para animais. Considerando todas essas informa\u00e7\u00f5es,\u00a0os biomarcadores como ferramenta diagn\u00f3stica s\u00f3 s\u00e3o poss\u00edveis dentro de ensaios cient\u00edficos<\/strong>.<\/p>\n

Refer\u00eancia<\/strong>: Tkaczyk and Jedziniak, 2021. Mycotoxin Biomarkers in Pigs\u2014Current State of Knowledge and Analytics. Toxins, 13, 586.<\/em>https:\/\/doi.org\/10.3390\/toxins13080586<\/em><\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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