{"id":6448,"date":"2023-01-02T10:41:57","date_gmt":"2023-01-02T10:41:57","guid":{"rendered":"https:\/\/olmix.com\/?p=6448"},"modified":"2025-01-14T15:10:57","modified_gmt":"2025-01-14T14:10:57","slug":"toxicidade-dos-novos-tricotecenos-nx-e-3anx-de-tipo-a","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/pt-pt\/toxicidade-dos-novos-tricotecenos-nx-e-3anx-de-tipo-a\/","title":{"rendered":"Toxicidade dos novos tricotecenos NX e 3ANX de tipo A"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; top_padding=&#8221;2%&#8221; constrain_group_4=&#8221;yes&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; 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column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;2%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;2%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;padding-2-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;left&#8221; left_margin=&#8221;7px&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;advanced&#8221; border_left_desktop=&#8221;1&#8243; column_border_color=&#8221;#007797&#8243; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][vc_column_text el_class=&#8221;med&#8221;]<strong>NX e sua forma acetilada 3ANX s\u00e3o dois novos tricotecenos tipo A produzidos pelo fungo\u00a0<em>Fusarium graminearum<\/em>.<\/strong>\u00a0O NX e o 3ANX s\u00e3o estruturalmente semelhantes ao desoxinivalenol (DON) e ao 3-ADON \u00a0do tricoteceno tipo B, respectivamente. Como o DON, o NX \u00e9 citot\u00f3xico, inibe a s\u00edntese de prote\u00ednas, desencadeia o estresse oxidativo e tem um efeito pr\u00f3-inflamat\u00f3rio.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; column_margin=&#8221;50px&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;2%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;2%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][image_with_animation image_url=&#8221;16711&#8243; image_size=&#8221;large&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; constrain_group_1=&#8221;yes&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221; margin_top=&#8221;20&#8243; margin_bottom=&#8221;20&#8243;][vc_column_text]Recentemente,\u00a0<strong>Pierron et al. investigou a toxicidade intestinal dessas toxinas rec\u00e9m-descobertas em compara\u00e7\u00e3o ao DON<\/strong>, usando c\u00e9lulas Caco-2 semelhantes \u00e0 enter\u00f3citos e explantes intestinais su\u00ednos.\u00a0A viabilidade das c\u00e9lulas intestinais expostas ao NX assemelhava-se \u00e0 do DON, enquanto o 3ANX apresentava menor citotoxicidade. Observa\u00e7\u00f5es histol\u00f3gicas tamb\u00e9m indicaram que\u00a0<strong>o NX causou maiores altera\u00e7\u00f5es nos explantes intestinais do que o DON<\/strong>; sendo o 3ANX o menos potente. Isso correlacionou o efeito das tr\u00eas toxinas no perfil de express\u00e3o g\u00eanica intestinal, o que indicou que o \u00a0NX tem mais impacto na express\u00e3o g\u00eanica intestinal do que o DON, e o 3ANX menos impacto. As mesmas vias de sinaliza\u00e7\u00e3o foram impactadas pelas tr\u00eas toxinas, especialmente as respostas inflamat\u00f3rias e imunes.<\/p>\n<p>Entretanto,\u00a0<strong>o NX modulou mais genes do que o DON ou 3ANX<\/strong>.\u00a0A regula\u00e7\u00e3o positiva dos genes inflamat\u00f3rios pode ser a causa da modifica\u00e7\u00e3o e degrada\u00e7\u00e3o dos tecidos intestinais. Espera-se que esse dano da morfologia intestinal tenha um impacto sobre a fun\u00e7\u00e3o de barreira e a absor\u00e7\u00e3o intestinal.<\/p>\n<p>Em suma,\u00a0<strong>os resultados indicam que o NX e o 3ANX t\u00eam padr\u00f5es t\u00f3xicos semelhantes aos do DON, p com diferentes graus de toxicidade: NX &gt; DON &gt;&gt; 3ANX<\/strong>. Em fun\u00e7\u00e3o disso, seria relevante incluir o NX na an\u00e1lise de risco ampla ligada \u00e0 presen\u00e7a de tricotecenos nos alimentos para animais.<\/p>\n<p><em><strong>Refer\u00eancia<\/strong>: Pierron\u00a0<\/em>et al.<em>, 2022. Intestinal toxicity of the new type A trichothecenes, NX and 3ANX. Chemosphere, 288, 132415.<\/em> <a href=\"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132415\" target=\"_blank\" rel=\"noopener\"><em>https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132415<\/em><\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; top_padding=&#8221;2%&#8221; constrain_group_4=&#8221;yes&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; gradient_type=&#8221;default&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221;&#8230;<\/p>\n","protected":false},"author":16,"featured_media":16706,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":{"0":"post-6448","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-myco-news-2"},"_links":{"self":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts\/6448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/comments?post=6448"}],"version-history":[{"count":2,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts\/6448\/revisions"}],"predecessor-version":[{"id":16716,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/posts\/6448\/revisions\/16716"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/media\/16706"}],"wp:attachment":[{"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/media?parent=6448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/categories?post=6448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mycokingdom.net\/pt-pt\/wp-json\/wp\/v2\/tags?post=6448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}