{"id":16876,"date":"2025-02-17T17:15:34","date_gmt":"2025-02-17T16:15:34","guid":{"rendered":"https:\/\/mycokingdom.net\/?p=16876"},"modified":"2025-02-17T17:15:34","modified_gmt":"2025-02-17T16:15:34","slug":"lieu-luong-deoxinivalenol-duoc-efsa-khuyen-cao-gay-anh-huong-den-suc-khoe-lon","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/vi\/lieu-luong-deoxinivalenol-duoc-efsa-khuyen-cao-gay-anh-huong-den-suc-khoe-lon\/","title":{"rendered":"Li\u1ec1u l\u01b0\u1ee3ng Deoxinivalenol \u0111\u01b0\u1ee3c EFSA khuy\u1ebfn c\u00e1o g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe l\u1ee3n"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_cta btn_style=”underline” heading_tag=”p” button_color=”default” text_color=”#269756″ button_border_thickness=”0px” link_type=”regular” alignment=”left” alignment_tablet=”default” alignment_phone=”default” display=”inline” display_tablet=”inherit” display_phone=”inherit” icon_family=”none” link_text=”Back to news” url=”\/mycotoxins-vn\/#news” text=”\u2190” font_size_desktop=”14px”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”horizontal” column_element_direction_tablet=”horizontal” column_element_direction_phone=”horizontal” column_element_alignment=”center” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#269756″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][nectar_icon icon_family=”fontawesome” icon_style=”default” icon_color_type=”color_scheme” icon_color=”Extra-Color-1″ icon_padding=”0px” pointer_events=”all” icon_fontawesome=”fa fa-clock-o” icon_size=”15″ margin_right=”7px” margin_top=”1px”][vc_column_text][rt_reading_time label=”Reading Time:” postfix=”minutes” postfix_singular=”minute”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#269756″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text css=”” el_class=”med” text_direction=”default”]N\u0103m ngo\u00e1i (th\u00e1ng 6 n\u0103m 2024), ch\u00fang t\u00f4i \u0111\u00e3 xu\u1ea5t b\u1ea3n Myco’News v\u1ec1 t\u00e1c d\u1ee5ng c\u1ee7a Deoxinivalenol (DON) li\u1ec1u th\u1ea5p \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe gia c\u1ea7m. Tuy nhi\u00ean, \u0111\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c ph\u1ed5 bi\u1ebfn n\u00e0y \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi m\u1ed9t s\u1ed1 lo\u00e0i Fusarium, c\u0169ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a l\u1ee3n \u1edf m\u1ee9c (900 ppb) Theo khuy\u1ebfn c\u00e1o c\u1ee7a EFSA.<\/p>\n

C\u00e1c t\u00e1c gi\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y – \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u1edf Ph\u00e1p – \u0111\u00e3 quan s\u00e1t th\u1ea5y c\u00e1c t\u1ed5n th\u01b0\u01a1ng trong ru\u1ed9t non \u1edf \u0111\u1ed9ng v\u1eadt ti\u1ebfp x\u00fac v\u1edbi DON. Nh\u1eefng thay \u0111\u1ed5i m\u00f4 h\u1ecdc ch\u00ednh \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf \u0111\u1ed9ng v\u1eadt \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng DON l\u00e0 s\u1ef1 teo v\u00e0 d\u00ednh l\u00f4ng nhung, c\u00f9ng v\u1edbi s\u1ef1 d\u1eb9t \u0111i c\u1ee7a t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t (H\u00ecnh 1). \u1ede c\u1ea5p \u0111\u1ed9 ph\u00e2n t\u1eed, xu h\u01b0\u1edbng gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u1ee7a cytokine v\u00e0 gen li\u00ean quan \u0111\u1ebfn ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch (IL-1\u03b2, IL-1\u03b1, IFN-\u03b3, TGF-\u03b21) \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf \u0111\u1ed9ng v\u1eadt nh\u1eadn th\u1ee9c \u0103n b\u1ecb nhi\u1ec5m 0,9 ppm DON so v\u1edbi \u0111\u1ed9ng v\u1eadt \u1edf l\u00f4 \u0111\u1ed1i ch\u1ee9ng.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”16792″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_column_text css=”” text_direction=”default”]H\u00ecnh 1. H\u00ecnh th\u00e1i \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a l\u1ee3n trong nh\u00f3m \u0111\u1ed1i ch\u1ee9ng (CTL), nh\u00f3m DON 0,9 v\u00e0 3 ppm. M\u00e0u t\u00edm l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a th\u1eed nghi\u1ec7m 1 v\u00e0 m\u00e0u xanh lam l\u00e0 th\u1eed nghi\u1ec7m 2.<\/em>[\/vc_column_text][vc_column_text css=”” text_direction=”default”]Ti\u1ebfp x\u00fac v\u1edbi DON c\u0169ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn gan c\u1ee7a l\u1ee3n. \u0102n ph\u1ea3i DON g\u00e2y r\u1ed1i lo\u1ea1n, kh\u00f4ng b\u00e0o h\u00f3a t\u1ebf b\u00e0o ch\u1ea5t kh\u00f4ng b\u00e0o h\u00f3a t\u1ebf b\u00e0o ch\u1ea5t v\u00e0 t\u0103ng b\u1ea1ch c\u1ea7u gan. S\u1ef1 s\u1ee5t gi\u1ea3m \u0111\u00e1ng k\u1ec3 trong bi\u1ec3u hi\u1ec7n gen c\u1ee7a ABCA1, li\u00ean quan \u0111\u1ebfn vi\u1ec7c v\u1eadn chuy\u1ec3n cholesterol, \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u00ecn th\u1ea5y \u1edf nh\u00f3m DON 0,9 ppm. C\u00e1c gen kh\u00e1c li\u00ean quan \u0111\u1ebfn ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch (IL-1\u03b1) v\u00e0 c\u1ea3m gi\u00e1c no (CCK) cho th\u1ea5y xu h\u01b0\u1edbng gi\u1ea3m bi\u1ec3u hi\u1ec7n \u1edf nh\u00f3m DON th\u1ea5p. Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c gen li\u00ean quan \u0111\u1ebfn stress oxy h\u00f3a (SOD1, SOD2) cho th\u1ea5y xu h\u01b0\u1edbng t\u0103ng bi\u1ec3u hi\u1ec7n.<\/p>\n

T\u00f3m l\u1ea1i, k\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y ch\u1ec9 ra r\u1eb1ng m\u1ee9c quy \u0111\u1ecbnh c\u1ee7a EU l\u00e0 0,9 mg DON\/kg th\u1ee9c \u0103n g\u00e2y ra c\u00e1c t\u1ed5n th\u01b0\u01a1ng trong ru\u1ed9t v\u00e0 gan, v\u00e0 \u0111i\u1ec1u ch\u1ec9nh ph\u1ea3n \u1ee9ng vi\u00eam. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y r\u1eb1ng m\u1ee9c khuy\u1ebfn ngh\u1ecb hi\u1ec7n t\u1ea1i n\u00ean \u0111\u01b0\u1ee3c xem x\u00e9t l\u1ea1i \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o s\u1ee9c kh\u1ecfe v\u00e0 t\u1ed1i \u01b0u ph\u00fac l\u1ee3i c\u1ee7a l\u1ee3n.[\/vc_column_text][vc_column_text css=”” text_direction=”default”]C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng nh\u1eefng thay \u0111\u1ed5i quan s\u00e1t \u0111\u01b0\u1ee3c trong h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t ch\u1ee7 y\u1ebfu li\u00ean quan \u0111\u1ebfn nh\u1eefng thay \u0111\u1ed5i do DON g\u00e2y ra \u0111\u1ed1i v\u1edbi qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t v\u00e0 ch\u1ee9c n\u0103ng ti\u00eau h\u00f3a c\u1ee7a v\u1eadt nu\u00f4i. Cu\u1ed1i c\u00f9ng, xu h\u01b0\u1edbng trong ru\u1ed9t c\u1ee7a g\u00e0 th\u1ecbt v\u00e0 l\u1ee3n c\u00f3 nh\u1eefng \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng c\u0169ng nh\u01b0 kh\u00e1c bi\u1ec7t. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn c\u01b0\u1eddng \u0111\u1ed9 \u0111\u1ed9c t\u00ednh do Don g\u00e2y ra \u1edf m\u1ed7i lo\u00e0i.[\/vc_column_text][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”accent-color” custom_height=”20″][vc_column_text css=”” text_direction=”default”]Tham kh\u1ea3o: Pierron A., Balbo LC, Soler, L., Pinton P., Puel S., Laffitte J., Albin M., Loureiro Bracarense AP., Rodriguez M v\u00e0 Oswald I. 2024. Deoxynivalenol g\u00e2y vi\u00eam c\u1ee5c b\u1ed9 v\u00e0 t\u1ed5n th\u01b0\u01a1ng trong m\u00f4 v\u1edbi li\u1ec1u l\u01b0\u1ee3ng khuy\u1ebfn c\u00e1o c\u1ee7a EU. T\u1ea1p ch\u00ed Khoa h\u1ecdc Ph\u00e2n t\u1eed Qu\u1ed1c t\u1ebf, 25, 9790. https:\/\/doi.org\/10.3390\/ijms25189790<\/strong><\/a><\/em>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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