{"id":17206,"date":"2026-06-08T16:04:52","date_gmt":"2026-06-08T14:04:52","guid":{"rendered":"https:\/\/mycokingdom.net\/doc-to-nam-moc-khi-ruot-doi-thoai-voi-gan\/"},"modified":"2026-06-08T16:04:52","modified_gmt":"2026-06-08T14:04:52","slug":"doc-to-nam-moc-khi-ruot-doi-thoai-voi-gan","status":"publish","type":"post","link":"https:\/\/mycokingdom.net\/vi\/doc-to-nam-moc-khi-ruot-doi-thoai-voi-gan\/","title":{"rendered":"\u0110\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c: khi ru\u1ed9t \u201c\u0111\u1ed1i tho\u1ea1i\u201d v\u1edbi gan"},"content":{"rendered":"
\n

M\u1ed9t b\u00e0i t\u1ed5ng quan \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n tr\u00ean Cell Biology and Toxicology v\u00e0o th\u00e1ng 2 v\u1eeba qua, t\u1ed5ng h\u1ee3p d\u1eef li\u1ec7u t\u1eeb 44 nghi\u00ean c\u1ee9u in vivo (2018\u20132025) \u0111\u00e3 l\u00e0m n\u1ed5i b\u1eadt m\u1ed9t kh\u00eda c\u1ea1nh c\u00f2n ch\u01b0a \u0111\u01b0\u1ee3c quan t\u00e2m \u0111\u00fang m\u1ee9c trong s\u1ee9c kh\u1ecfe \u0111\u1ed9ng v\u1eadt: m\u1ed1i t\u01b0\u01a1ng t\u00e1c gi\u1eefa \u0111\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c, h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan.<\/strong><\/p>\n

M\u1ed1i li\u00ean h\u1ec7 ch\u1eb7t ch\u1ebd gi\u1eefa r\u1ed1i lo\u1ea1n h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 t\u1ed5n th\u01b0\u01a1ng gan<\/strong><\/h2>\n

M\u1ed9t trong nh\u1eefng th\u00f4ng \u0111i\u1ec7p ch\u00ednh c\u1ee7a b\u00e0i t\u1ed5ng quan l\u00e0 s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i ti\u1ebfp c\u1eadn s\u1ee9c kh\u1ecfe \u0111\u1ed9ng v\u1eadt theo h\u01b0\u1edbng to\u00e0n di\u1ec7n th\u00f4ng qua tr\u1ee5c ru\u1ed9t \u2013 gan. Nh\u1eefng thay \u0111\u1ed5i c\u1ee7a h\u1ec7 vi sinh v\u1eadt do ph\u01a1i nhi\u1ec3m v\u1edbi c\u00e1c \u0111\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c (\u0111\u1eb7c bi\u1ec7t l\u00e0 DON, AFB1, ZEN ho\u1eb7c OTA), d\u1eabn \u0111\u1ebfn t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a h\u00e0ng r\u00e0o ru\u1ed9t, t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho c\u00e1c h\u1ee3p ch\u1ea5t g\u00e2y vi\u00eam t\u00e1c \u0111\u1ed9ng v\u00e0o gan. \u0110i\u1ec1u n\u00e0y k\u00edch ho\u1ea1t stress oxy h\u00f3a, ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o gan. Nh\u1eefng bi\u1ebfn \u0111\u1ed5i n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c ghi nh\u1eadn th\u00f4ng qua s\u1ef1 gia t\u0103ng c\u00e1c enzyme ch\u1ee7 ch\u1ed1t (ALT, AST) v\u00e0 c\u00e1c d\u1ea5u \u1ea5n oxy h\u00f3a. <\/p>\n

C\u01a1 ch\u1ebf \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t: khi h\u00e0ng r\u00e0o ru\u1ed9t b\u1ecb suy y\u1ebfu, gan tr\u1edf th\u00e0nh tuy\u1ebfn ph\u00f2ng th\u1ee7 \u0111\u1ea7u ti\u00ean<\/strong><\/h2>\n

C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y nh\u1eefng thay \u0111\u1ed5i l\u1eb7p \u0111i l\u1eb7p l\u1ea1i c\u1ee7a h\u1ec7 vi sinh v\u1eadt, \u0111\u1eb7c tr\u01b0ng b\u1edfi s\u1ef1 suy gi\u1ea3m c\u00e1c lo\u00e0i vi khu\u1ea9n b\u1ea3o v\u1ec7 v\u00e0\/ho\u1eb7c vi khu\u1ea9n s\u1ea3n xu\u1ea5t axit b\u00e9o chu\u1ed7i ng\u1eafn (SCFA) nh\u01b0 Akkermansia, Roseburia, Prevotella, \u0111\u1ed3ng th\u1eddi gia t\u0103ng c\u00e1c nh\u00f3m vi khu\u1ea9n c\u00f3 xu h\u01b0\u1edbng g\u00e2y vi\u00eam nh\u01b0 Proteobacteria. S\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng n\u00e0y l\u00e0m suy gi\u1ea3m t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o ru\u1ed9t, \u0111\u1eb7c bi\u1ec7t l\u00e0 l\u00e0m thay \u0111\u1ed5i ch\u1ea5t nh\u1ea7y v\u00e0 c\u00e1c li\u00ean k\u1ebft ch\u1eb7t gi\u1eefa c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u m\u00f4, t\u1eeb \u0111\u00f3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho \u0111\u1ed9c t\u1ed1 v\u00e0 c\u00e1c h\u1ee3p ch\u1ea5t g\u00e2y vi\u00eam \u0111i v\u00e0o gan. <\/p>\n

T\u00e1c \u0111\u1ed9ng k\u1ebft h\u1ee3p<\/strong><\/h2>\n

B\u00e0i b\u00e1o nh\u1ea5n m\u1ea1nh t\u00e1c \u0111\u1ed9ng \u0111\u1ed3ng th\u1eddi c\u1ee7a \u0111\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c l\u00ean ch\u1ee9c n\u0103ng gan v\u00e0 h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t, l\u00e0m t\u0103ng c\u01b0\u1eddng c\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i th\u00f4ng qua c\u00e1c c\u01a1 ch\u1ebf k\u1ebft h\u1ee3p nh\u01b0 g\u00e2y stress oxy h\u00f3a, k\u00edch ho\u1ea1t mi\u1ec5n d\u1ecbch v\u00e0 r\u1ed1i lo\u1ea1n h\u1ec7 vi sinh.<\/p>\n

B\u1eb1ng vi\u1ec7c l\u00e0m r\u00f5 c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c hai chi\u1ec1u gi\u1eefa ru\u1ed9t v\u00e0 gan, nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 kh\u1eb3ng \u0111\u1ecbnh vai tr\u00f2 then ch\u1ed1t c\u1ee7a h\u1ec7 vi sinh v\u1eadt trong c\u01a1 ch\u1ebf g\u00e2y \u0111\u1ed9c c\u1ee7a \u0111\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c, \u0111\u1ed3ng th\u1eddi m\u1edf ra c\u00e1c chi\u1ebfn l\u01b0\u1ee3c qu\u1ea3n l\u00fd v\u00e0 ph\u00f2ng ng\u1eeba d\u1ef1a tr\u00ean gi\u1ea3i ph\u00e1p \u0111i\u1ec1u h\u00f2a h\u1ec7 vi sinh v\u1eadt.<\/p>\n

 <\/p>\n

Tham kh\u1ea3o :<\/em>
\nL\u00e1zaro, \u00c1., Frangiamone, M., de las Heras, M. v\u00e0 c\u1ed9ng s\u1ef1. \u0110\u1ed9c t\u1ed1 n\u1ea5m m\u1ed1c, thay \u0111\u1ed5i h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 b\u1ec7nh gan \u1edf \u0111\u1ed9ng v\u1eadt: M\u1ed9t t\u1ed5ng quan ph\u1ea1m vi. Cell Biol Toxicol 42, 39 (2026). https:\/\/doi.org\/10.1007\/s10565-026-10156-5<\/a><\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t b\u00e0i t\u1ed5ng quan \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n tr\u00ean Cell Biology and Toxicology v\u00e0o th\u00e1ng 2 v\u1eeba qua, t\u1ed5ng h\u1ee3p d\u1eef li\u1ec7u t\u1eeb 44 nghi\u00ean c\u1ee9u in vivo (2018\u20132025) \u0111\u00e3 l\u00e0m…<\/p>\n","protected":false},"author":3,"featured_media":17201,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60,62,63,59,61],"tags":[],"class_list":["post-17206","post","type-post","status-publish","format-standard","has-post-thumbnail","category-myco-news-vi","category-myco-news-vi-2","category-myco-news-vi-3","category-myconews-vi","category-vn-vi"],"_links":{"self":[{"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/posts\/17206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/comments?post=17206"}],"version-history":[{"count":0,"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/posts\/17206\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/media\/17201"}],"wp:attachment":[{"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/media?parent=17206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/categories?post=17206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mycokingdom.net\/vi\/wp-json\/wp\/v2\/tags?post=17206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}